il 36r Search Results


nm 003854  (OriGene)
90
OriGene nm 003854
Nm 003854, supplied by OriGene, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/nm 003854/product/OriGene
Average 90 stars, based on 1 article reviews
nm 003854 - by Bioz Stars, 2026-03
90/100 stars
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anti-il-36r blocking antibody m616  (Amgen)
90
Amgen anti-il-36r blocking antibody m616
Anti Il 36r Blocking Antibody M616, supplied by Amgen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/anti-il-36r blocking antibody m616/product/Amgen
Average 90 stars, based on 1 article reviews
anti-il-36r blocking antibody m616 - by Bioz Stars, 2026-03
90/100 stars
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anti-human il-36r antibody  (Bio X Cell)
90
Bio X Cell anti-human il-36r antibody
Anti Human Il 36r Antibody, supplied by Bio X Cell, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/anti-human il-36r antibody/product/Bio X Cell
Average 90 stars, based on 1 article reviews
anti-human il-36r antibody - by Bioz Stars, 2026-03
90/100 stars
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human il-36r  (ACROBiosystems)
90
ACROBiosystems human il-36r
Human Il 36r, supplied by ACROBiosystems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/human il-36r/product/ACROBiosystems
Average 90 stars, based on 1 article reviews
human il-36r - by Bioz Stars, 2026-03
90/100 stars
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sepsis model il36r−/− mice  (Cyagen Biosciences)
90
Cyagen Biosciences sepsis model il36r−/− mice
Sepsis Model Il36r−/− Mice, supplied by Cyagen Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/sepsis model il36r−/− mice/product/Cyagen Biosciences
Average 90 stars, based on 1 article reviews
sepsis model il36r−/− mice - by Bioz Stars, 2026-03
90/100 stars
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humanized anti-human il-36r mab hb0034  (Shanghai Model Organisms Center)
90
Shanghai Model Organisms Center humanized anti-human il-36r mab hb0034
HB0043 retained the affinities and blockade activity to both targets. (A) Schematics of the anti-IL-36R×IL-17A BsAb (HB0043) structure. HB0043 was constructed by linking a scFv targeting IL-36R to the C-terminal domain of the anti-IL-17A IgG backbone. (B) The kinetics profile of HB0043 and HB0017 (the parental anti-IL-17A mAb) binding to human IL-17A, and human IL-36R binding to HB0043 and <t>HB0034</t> (the parental anti-IL-36R mAb) measured by SPR assay. (C) The ability of HB0043 to neutralize IL-17A signaling was measured and compared to that of HB0017, using an IL-17A blockade cell-based assay. The secretion of IL-6 was monitored, which was induced by human IL-17A (0.3 nM) and TNF-α (0.6 nM) in HT-1080 cell. (D) The inhibition of IL-6 releases from NCI/ADR-RES cells was used as an evaluation of IL-36R signaling inhibition. NCI/ADR-RES cells were stimulated with human IL36α (13.5 nM) in the presence of HB0043 (32 pM to 245 nM) and HB0034 (4 pM to 336 nM).
Humanized Anti Human Il 36r Mab Hb0034, supplied by Shanghai Model Organisms Center, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/humanized anti-human il-36r mab hb0034/product/Shanghai Model Organisms Center
Average 90 stars, based on 1 article reviews
humanized anti-human il-36r mab hb0034 - by Bioz Stars, 2026-03
90/100 stars
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rabbit anti-il-36 r pab (human/mouse cross-reactive)  (ABclonal Biotechnology)
90
ABclonal Biotechnology rabbit anti-il-36 r pab (human/mouse cross-reactive)
HB0043 retained the affinities and blockade activity to both targets. (A) Schematics of the anti-IL-36R×IL-17A BsAb (HB0043) structure. HB0043 was constructed by linking a scFv targeting IL-36R to the C-terminal domain of the anti-IL-17A IgG backbone. (B) The kinetics profile of HB0043 and HB0017 (the parental anti-IL-17A mAb) binding to human IL-17A, and human IL-36R binding to HB0043 and <t>HB0034</t> (the parental anti-IL-36R mAb) measured by SPR assay. (C) The ability of HB0043 to neutralize IL-17A signaling was measured and compared to that of HB0017, using an IL-17A blockade cell-based assay. The secretion of IL-6 was monitored, which was induced by human IL-17A (0.3 nM) and TNF-α (0.6 nM) in HT-1080 cell. (D) The inhibition of IL-6 releases from NCI/ADR-RES cells was used as an evaluation of IL-36R signaling inhibition. NCI/ADR-RES cells were stimulated with human IL36α (13.5 nM) in the presence of HB0043 (32 pM to 245 nM) and HB0034 (4 pM to 336 nM).
Rabbit Anti Il 36 R Pab (Human/Mouse Cross Reactive), supplied by ABclonal Biotechnology, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit anti-il-36 r pab (human/mouse cross-reactive)/product/ABclonal Biotechnology
Average 90 stars, based on 1 article reviews
rabbit anti-il-36 r pab (human/mouse cross-reactive) - by Bioz Stars, 2026-03
90/100 stars
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il-36r −/- mice  (Taconic Biosciences)
90
Taconic Biosciences il-36r −/- mice
HB0043 retained the affinities and blockade activity to both targets. (A) Schematics of the anti-IL-36R×IL-17A BsAb (HB0043) structure. HB0043 was constructed by linking a scFv targeting IL-36R to the C-terminal domain of the anti-IL-17A IgG backbone. (B) The kinetics profile of HB0043 and HB0017 (the parental anti-IL-17A mAb) binding to human IL-17A, and human IL-36R binding to HB0043 and <t>HB0034</t> (the parental anti-IL-36R mAb) measured by SPR assay. (C) The ability of HB0043 to neutralize IL-17A signaling was measured and compared to that of HB0017, using an IL-17A blockade cell-based assay. The secretion of IL-6 was monitored, which was induced by human IL-17A (0.3 nM) and TNF-α (0.6 nM) in HT-1080 cell. (D) The inhibition of IL-6 releases from NCI/ADR-RES cells was used as an evaluation of IL-36R signaling inhibition. NCI/ADR-RES cells were stimulated with human IL36α (13.5 nM) in the presence of HB0043 (32 pM to 245 nM) and HB0034 (4 pM to 336 nM).
Il 36r −/ Mice, supplied by Taconic Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/il-36r −/- mice/product/Taconic Biosciences
Average 90 stars, based on 1 article reviews
il-36r −/- mice - by Bioz Stars, 2026-03
90/100 stars
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sirnas targeting human cd93, il-36r, ddxs and sf2  (Shanghai GenePharma)
90
Shanghai GenePharma sirnas targeting human cd93, il-36r, ddxs and sf2
HB0043 retained the affinities and blockade activity to both targets. (A) Schematics of the anti-IL-36R×IL-17A BsAb (HB0043) structure. HB0043 was constructed by linking a scFv targeting IL-36R to the C-terminal domain of the anti-IL-17A IgG backbone. (B) The kinetics profile of HB0043 and HB0017 (the parental anti-IL-17A mAb) binding to human IL-17A, and human IL-36R binding to HB0043 and <t>HB0034</t> (the parental anti-IL-36R mAb) measured by SPR assay. (C) The ability of HB0043 to neutralize IL-17A signaling was measured and compared to that of HB0017, using an IL-17A blockade cell-based assay. The secretion of IL-6 was monitored, which was induced by human IL-17A (0.3 nM) and TNF-α (0.6 nM) in HT-1080 cell. (D) The inhibition of IL-6 releases from NCI/ADR-RES cells was used as an evaluation of IL-36R signaling inhibition. NCI/ADR-RES cells were stimulated with human IL36α (13.5 nM) in the presence of HB0043 (32 pM to 245 nM) and HB0034 (4 pM to 336 nM).
Sirnas Targeting Human Cd93, Il 36r, Ddxs And Sf2, supplied by Shanghai GenePharma, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/sirnas targeting human cd93, il-36r, ddxs and sf2/product/Shanghai GenePharma
Average 90 stars, based on 1 article reviews
sirnas targeting human cd93, il-36r, ddxs and sf2 - by Bioz Stars, 2026-03
90/100 stars
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il-36r antagonist  (CH Instruments)
90
CH Instruments il-36r antagonist
The treatments targeting of lymphocytes in vivo .
Il 36r Antagonist, supplied by CH Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/il-36r antagonist/product/CH Instruments
Average 90 stars, based on 1 article reviews
il-36r antagonist - by Bioz Stars, 2026-03
90/100 stars
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anti-il-36r_bm2-higg4-a647  (Innovagen AB)
90
Innovagen AB anti-il-36r_bm2-higg4-a647
The treatments targeting of lymphocytes in vivo .
Anti Il 36r Bm2 Higg4 A647, supplied by Innovagen AB, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/anti-il-36r_bm2-higg4-a647/product/Innovagen AB
Average 90 stars, based on 1 article reviews
anti-il-36r_bm2-higg4-a647 - by Bioz Stars, 2026-03
90/100 stars
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il-36r– deficient mice (il-136r /)  (Jackson Laboratory)
90
Jackson Laboratory il-36r– deficient mice (il-136r /)
The treatments targeting of lymphocytes in vivo .
Il 36r– Deficient Mice (Il 136r /), supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/il-36r– deficient mice (il-136r /)/product/Jackson Laboratory
Average 90 stars, based on 1 article reviews
il-36r– deficient mice (il-136r /) - by Bioz Stars, 2026-03
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Image Search Results


HB0043 retained the affinities and blockade activity to both targets. (A) Schematics of the anti-IL-36R×IL-17A BsAb (HB0043) structure. HB0043 was constructed by linking a scFv targeting IL-36R to the C-terminal domain of the anti-IL-17A IgG backbone. (B) The kinetics profile of HB0043 and HB0017 (the parental anti-IL-17A mAb) binding to human IL-17A, and human IL-36R binding to HB0043 and HB0034 (the parental anti-IL-36R mAb) measured by SPR assay. (C) The ability of HB0043 to neutralize IL-17A signaling was measured and compared to that of HB0017, using an IL-17A blockade cell-based assay. The secretion of IL-6 was monitored, which was induced by human IL-17A (0.3 nM) and TNF-α (0.6 nM) in HT-1080 cell. (D) The inhibition of IL-6 releases from NCI/ADR-RES cells was used as an evaluation of IL-36R signaling inhibition. NCI/ADR-RES cells were stimulated with human IL36α (13.5 nM) in the presence of HB0043 (32 pM to 245 nM) and HB0034 (4 pM to 336 nM).

Journal: Frontiers in Immunology

Article Title: Dual blockade of IL-17A and IL-36 pathways via a bispecific antibody exhibits enhanced anti-inflammatory potency

doi: 10.3389/fimmu.2024.1434127

Figure Lengend Snippet: HB0043 retained the affinities and blockade activity to both targets. (A) Schematics of the anti-IL-36R×IL-17A BsAb (HB0043) structure. HB0043 was constructed by linking a scFv targeting IL-36R to the C-terminal domain of the anti-IL-17A IgG backbone. (B) The kinetics profile of HB0043 and HB0017 (the parental anti-IL-17A mAb) binding to human IL-17A, and human IL-36R binding to HB0043 and HB0034 (the parental anti-IL-36R mAb) measured by SPR assay. (C) The ability of HB0043 to neutralize IL-17A signaling was measured and compared to that of HB0017, using an IL-17A blockade cell-based assay. The secretion of IL-6 was monitored, which was induced by human IL-17A (0.3 nM) and TNF-α (0.6 nM) in HT-1080 cell. (D) The inhibition of IL-6 releases from NCI/ADR-RES cells was used as an evaluation of IL-36R signaling inhibition. NCI/ADR-RES cells were stimulated with human IL36α (13.5 nM) in the presence of HB0043 (32 pM to 245 nM) and HB0034 (4 pM to 336 nM).

Article Snippet: Animal use for generation of humanized anti-human IL-36R mAb HB0034 and anti-mouse IL-36R mAb had approvals of IACUC of Shanghai Model Organisms.

Techniques: Activity Assay, Construct, Binding Assay, SPR Assay, Cell Based Assay, Inhibition

Binding affinity of BsAbs and mAbs to the targets from different species.

Journal: Frontiers in Immunology

Article Title: Dual blockade of IL-17A and IL-36 pathways via a bispecific antibody exhibits enhanced anti-inflammatory potency

doi: 10.3389/fimmu.2024.1434127

Figure Lengend Snippet: Binding affinity of BsAbs and mAbs to the targets from different species.

Article Snippet: Animal use for generation of humanized anti-human IL-36R mAb HB0034 and anti-mouse IL-36R mAb had approvals of IACUC of Shanghai Model Organisms.

Techniques: Binding Assay

HB0043 effectively antagonized the production of IL-6 induced by IL-17A and IL-36 in NHDF cells. (A–C) The ability of HB0043 to block IL-36R signaling and IL-17A signaling was measured and compared to that of HB0034 and HB0017, using IL-17A and IL-36R blockade cell-based assay. The secretion of IL-6 was monitored, which was induced by 0.5 ng/ml human IL-17A and 15 ng/ml IL-36α (A) , 1 ng/ml IL-36β (B) or 2 ng/ml IL-36γ (C) in NHDF cells overnight. Data are expressed as means ± SEM, n=3. *P<0.05, **P<0.01, ***P<0.01, ****P < 0.0001, as determined by one-way ANOVA.

Journal: Frontiers in Immunology

Article Title: Dual blockade of IL-17A and IL-36 pathways via a bispecific antibody exhibits enhanced anti-inflammatory potency

doi: 10.3389/fimmu.2024.1434127

Figure Lengend Snippet: HB0043 effectively antagonized the production of IL-6 induced by IL-17A and IL-36 in NHDF cells. (A–C) The ability of HB0043 to block IL-36R signaling and IL-17A signaling was measured and compared to that of HB0034 and HB0017, using IL-17A and IL-36R blockade cell-based assay. The secretion of IL-6 was monitored, which was induced by 0.5 ng/ml human IL-17A and 15 ng/ml IL-36α (A) , 1 ng/ml IL-36β (B) or 2 ng/ml IL-36γ (C) in NHDF cells overnight. Data are expressed as means ± SEM, n=3. *P<0.05, **P<0.01, ***P<0.01, ****P < 0.0001, as determined by one-way ANOVA.

Article Snippet: Animal use for generation of humanized anti-human IL-36R mAb HB0034 and anti-mouse IL-36R mAb had approvals of IACUC of Shanghai Model Organisms.

Techniques: Blocking Assay, Cell Based Assay

Nonclinical safety evaluation in cynomolgus monkeys.

Journal: Frontiers in Immunology

Article Title: Dual blockade of IL-17A and IL-36 pathways via a bispecific antibody exhibits enhanced anti-inflammatory potency

doi: 10.3389/fimmu.2024.1434127

Figure Lengend Snippet: Nonclinical safety evaluation in cynomolgus monkeys.

Article Snippet: Animal use for generation of humanized anti-human IL-36R mAb HB0034 and anti-mouse IL-36R mAb had approvals of IACUC of Shanghai Model Organisms.

Techniques: Concentration Assay

Single-dose pharmacokinetic study in cynomolgus monkeys.

Journal: Frontiers in Immunology

Article Title: Dual blockade of IL-17A and IL-36 pathways via a bispecific antibody exhibits enhanced anti-inflammatory potency

doi: 10.3389/fimmu.2024.1434127

Figure Lengend Snippet: Single-dose pharmacokinetic study in cynomolgus monkeys.

Article Snippet: Animal use for generation of humanized anti-human IL-36R mAb HB0034 and anti-mouse IL-36R mAb had approvals of IACUC of Shanghai Model Organisms.

Techniques:

The treatments targeting of lymphocytes in vivo .

Journal: Frontiers in Physiology

Article Title: Lymphocytes: Versatile Participants in Acute Kidney Injury and Progression to Chronic Kidney Disease

doi: 10.3389/fphys.2021.729084

Figure Lengend Snippet: The treatments targeting of lymphocytes in vivo .

Article Snippet: The administration of an IL-36R antagonist after UUO attenuated tubulointerstitial lesions (TILs) that might be associated with the reduction of Th17 differentiation (Chi et al., ).

Techniques: In Vivo, Activity Assay, Activation Assay, Histone Deacetylase Assay